Recent key publications:


Ternary complex C3b-FH-FI reveals molecular mechanisms underlying Cofactor Activity and complement-imme processing
C3b-Factor H-Factor I
Xue et al. Nature SMB (2016)
Commentary in Complement Highlights

Heterogeneous MAC initiator and pore structures in a lipid bilayer by phase-plate cryo-electron tomography
MAC vesicle
Sharp et al. Cell Reports (2016)
Commentary in Complement Highlights

Regulators of complement activity mediate inhibitory mechanisms through common C3b-binding mode
C3b regulator complexes
Formeris et al. EMBO Journal (2016)
Commentary in Complement Highlights

Complement is activated by IgG hexamers assembled at the cell surface
IgG-C1 complex
Diebolder, Beurskens et al. Science (2014)
Commentary in Complement Highlights

Stem cell

Stem cell growth factor R-spondin 1 in complex witt the ectodomain of its receptor LGR5
LGR5-Rspo1 dimer Peng, de Lau et al. Cell Reports (2013)

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling
ZRNF3-Rspo1 complex Peng et al. PLoS ONE (2013)
Protein dynamics

Modelling dynamics in protein crystal structures by ensemble refinement
ensemble model of 3K0N
Burnley et al. eLife (2012)

Research highlights:

Please use the contents bar on top to navigate through our research pages with topics: complement system, plasma proteins, outer-membrane proteins, crystallographic methods and data repository.

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