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Gros Lab

Crystal and Structural Chemistry
Bijvoet Centre for Biomolecular Research
Department of Chemistry, Faculty of Science
Utrecht University

email: p.grosuu.nl

Research Areas

Complement System

Plasma & Membrane Proteins

Crystallographic Method Development

Major Techniques

X-ray Crystallography

Cryo-Electron Microscopy

Biophysical Characterisation


Current Vacancies/Projects

Post-Doc Vacancies

There is currently one 2.5-year ERC-funded post-doctoral positions available on structural, biophysical and biochemical studies of the human complement system.

Please send applications (consisting of a CV, a motivation letter and two references) to science.secr.ks@uu.nl.


Research Highlights

STEAP4
Metal Homeostasis

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.

C1q
Cryo-EM of C1-IgG1 complex

C1 binds heterogeneously to IgG1-Fc hexamer complexes

C3b-Factor H-Factor I
Complement Regulation

Ternary complex C3b-FH-FI reveals molecular mechanisms underlying Cofactor Activity and complement-immune processing

MAC vesicle
Complement Lysis

Heterogeneous MAC initiator and pore structures in a lipid bilayer by phase-plate cryo-electron tomography

C3b regulator complexes
Complement Regulation

Regulators of complement activity mediate inhibitory mechanisms through common C3b-binding mode

IgG-C1 complex
Complement Activation

Complement is activated by IgG hexamers assembled at the cell surface

LGR5-Rspo1 dimer
Stem Cells

Stem cell growth factor R-spondin 1 in complex witt the ectodomain of its receptor LGR5

ZRNF3-Rspo1 complex
Stem Cells

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling

ensemble model of 3K0N
Ensemble Refinement

Modelling dynamics in protein crystal structures by ensemble refinement


Videos & Lectures

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